Publications

2018
in press Sun B-J, Ma L, Li S-R, Williams CM, Wan g Y, Hao X, Du W-G (in press) Phenology and the physiological niche are co-adapted in a desert-dwelling lizard. Functional Ecology.
2018 Halbritter DA, Teets NM, Williams CM, Daniels JC. Differences in winter cold hardiness support the geographic range disjunction of Neophasia menapia and Neophasia terlooii (Lepidoptera: Pieridae) Journal of Insect Physiology 107:204-211.
2018 Visser B, Williams CM, Hahn DA, Lopez-Martinez GC. Hormetic benefits of prior anoxia exposure in buffering anoxia stress in a soil-pupating insect.  Journal of Experimental Biology 221, doi:10.1242/jeb.167825.
2018 Williams CM, Rocca JR, Edison AS, Allison DB, Morgan TJ, Hahn DA. Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster. Integrative Zoology 13:471-81.
2017
2017 Early career researchers: a conversation with Caroline Williams. Journal of Experimental Biology 220: 2133-2135. Interviewer Kathryn Knight.
2017 Hatle JD, Awan A, Nicholas J, Koch R, Vokrri JR, McCue MD, Williams CM, Davidowitz G, Hahn DA. Life-extending dietary restriction and ovariectomy each have distinct effects on nutrient oxidation and allocation in grasshoppers, especially for leucine. Experimental Gerontology 96:155-161.
2017  Williams CM, Ragland GJ, Betini G, Buckley LB, Cheviron Z, Donohue K, Hereford J, Humphries MM, Lisovski S, Marshall KE, Schmidt PS, Sheldon K, Varpe O, Visser ME. Understanding evolutionary impacts of seasonality: an introduction to the symposium. Integrative and Comparative Biology 57: 921-933.
2016
2016  Williams CM, McCue MD, Sunny NE, Szejner-Sigal A, Morgan TJ, Edison AS, Allison DB, Hahn DA. Cold adaptation increases rates of nutrient flow and metabolic plasticity during cold exposure in Drosophila melanogaster. Proceedings of the Royal Society B: Biological Sciences. DOI 10.1098/rspb.2016.1317.
2016  Williams CM Ecology: Insect Thermal Baggage. Nature Climate Change (News and Views) 6: 543-544.
2016  Williams CM, Szejner-Sigal AU, Morgan TJ, Edison AS, Allison DB, Hahn DA. Adaptation to low temperature exposure increases metabolic rates independently of metabolic rates. Integrative and Comparative Biology 56: 62-72.
2016  Williams CM, Buckley LB, Sheldon KS, Vickers M, Pörtner H-O, Dowd WW, Gunderson AR, Marshall KE, Stillman JH.  Biological impacts of thermal extremes: mechanisms and costs of functional responses matter. Integrative and Comparative Biology 56: 73-84.
2016  Patterson RE, Kalavalapalli S, Williams CM, Nautiyal M, Mathew J., Martinez J, Reinhard MK, McDougall D, Rocca JR, Yost RA, Cusi K, Garrett TJ, Sunny NE. Lipotoxicity in steatohepatitis occurs despite an increase in TCA cycle activity. American Journal of Physiology: Endocrinology and Metabolism 310:E484-494.
2016 Sunny NE, Kalavalapalli S, Bril F, Garrett TJ, Nautiyal M, Mathew JT, Williams CM, Cusi K. Crosstalk between branched chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease. American Journal of Physiology: Endocrinology and Metabolism 309:E311-319.
2015
2015 Williams CM, Sinclair BJ, Chick WD A cross-seasonal perspective on local adaptation: Cover imageMetabolic plasticity mediates responses to winter in a thermal-generalist moth species. Functional Ecology 29: 549-561. COVER PHOTO.
2015  Williams CM, Henry HAL, Sinclair BJ. Cold truths: how winter drives responses for terrestrial organisms to climate change. Biological Reviews 90:214-235. Recommended, Faculty of 1000.
2014
2014 Williams CM, Watanabe M, Guarracino M, Ferraro MB, Edison AE, Morgan TJ, Boroujerdi AFB, Hahn DA. Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster. Evolution 68: 3505-3523.
2014 Clendinen CS, Lee-McMullen B, Williams CM, Stupp G, Vandenborne K, Hahn DA, Walter GA, Edison AS. 13C NMR Metabolomics: Applications at Natural Abundance. Analytical Chemistry 86: 9242-9250.
2014  Williams CM, Nicolai A, Ferguson, LV, Bernards MA, Hellmann JJ, Sinclair BJ. Cold hardiness and deacclimation of overwintering Papilio zelicaon pupae. Comparative Biochemistry and Physiology A: Molecular and Integrative Physiology, 178:51-58.
2014 O’Neil ST, Dzurisin JDK, Williams CM, Lobo NF, Higgins JK, Deines JM, Carmichael RD, Zeng E, Tan JC, Wu GC, Emrich SJ, Hellmann JJ. Gene expression in closely-related species mirrors local adaptation: consequences for responses to a warming world. Molecular Ecology 23:2686-2698.
2013
2013 Lake, SL, MacMillan, HA, Williams, CM, Sinclair, BJ. Static and dynamic approaches yield similar estimates of thermal sensitivity of insect metabolism. Journal of Insect Physiology 59:761-766. 
2013  Jensen K, Sanchez-Garcia J, Williams CM, Khare S, Mathur K, Graze RM, Hahn DA, McIntyre LM, Rincon-Limas D, Fernandez-Funez P. Purification of transcripts and metabolites from Drosophila heads. Journal of Visualised Experiments 73: e50245.
2013 Sinclair BJ, Stinziano JR, Williams CM, MacMillan HA, Marshall KE, Storey KB. Real-time measurements of metabolic rate during freezing and thawing of the wood frog, Rana sylvatica: implications for overwinter energy use. Journal of Experimental Biology 216:292-302.
2012
2012  MacMillan HA, Williams CM, Staples JF, Sinclair BJ. Reestablishment of ion homeostasis during insect chill coma recovery. Proceedings of the National Academy of Sciences U.S.A.doi: 10.1073/pnas.1212788109.
2012 Sinclair BJ, Williams CM; Terblanche JS. Variation in thermal performance among insect populations. Physiological and Biochemical Zoology 85:594-606.
2012 Williams CM, Hellmann JJ, Sinclair BJ. Lepidopteran species differ in susceptibility to winter warming.  Climate Research 53:119-130.
2012 Williams CM, Marshall KE, MacMillan HA, Dzurisin JDK, Hellmann JJ, SinclairBJ. Thermal variability increases the impact of autumnal warming and drives metabolic depression in an overwintering butterfly.  PLoS ONE 7:e34470.
2012  MacMillan HA; Williams CM; Staples JF; Sinclair BJ. Metabolism and energy supply below the critical thermal minimum of a chill-susceptible insect. Journal of Experimental Biology215: 1366-1372.
2011
2011 Williams CM, Thomas RH; MacMillan HA; Marshall KE; Sinclair BJ. Triacylglyceride measurement in small quantities of homogenised insect tissue: comparisons and caveats. Journal of Insect Physiology 57:1602-1613.
2011  Lalouette L; Williams CM; Cottin M; Sinclair BJ; Renault D. Thermal biology of the alien ground beetle Merizodus soledadinus introduced to the Kerguelen Islands. Polar Biology 35: 509-517.
2011  Lalouette L, Williams CM, Hervant F, Sinclair BJ, Renault D. Metabolic rate and oxidative stress in insects exposed to low temperature thermal fluctuations. Comparative Biochemistry and Physiology A 158:229-34.
2010
2010  Bazinet AL; Marshall KE; MacMillan HA; Williams CM; Sinclair BJ. Rapid changes in desiccation resistance in Drosophila melanogaster are facilitated by changes in cuticular permeability. Journal of Insect Physiology 56:2006-12.
2010  Williams CM, Pelini SL, Hellmann JJ, Sinclair BJ. Intra-individual variation allows an explicit test of the hygric hypothesis for discontinuous gas exchange in insects. Biology Letters, 6: 274-277.
2009
2009  Pelini SL, Dzurisin JDK, Prior KM, Williams CM, Marsico TD, Sinclair BJ, Hellmann JJ. Translocation experiments with butterflies reveal limits to enhancement of poleward populations under climate change. Proceedings of the National Academy of Sciences U.S.A.106:11160-5.
2003
2003  Williams CM, Poulin R, Sinclair BJ. Increased haemolymph osmolality suggests a new route for behavioral manipulation of Talorchestia quoyana (Amphipoda: Talitridae) by its mermithid parasite. Functional Ecology 18:685-91.